Description

1-(3-Fluoro-5-Trifluoromethylpyridin-2-Yl)Piperazine is a high-value, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in its unique molecular architecture, which combines a piperazine ring with a multi-fluorinated pyridine moiety, offering versatile reactivity and the ability to modulate key physicochemical properties in target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the design and synthesis of novel active ingredients. Its application is critical in projects requiring the introduction of fluorine atoms to enhance metabolic stability, bioavailability, or binding affinity.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in central nervous system (CNS) and oncology therapeutic areas.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides where the fluorine atoms improve environmental stability and efficacy.
• Material Science Precursor: Serves as a building block for advanced organic electronic materials and liquid crystals.
• Chemical Biology Probes: Employed in the creation of fluorinated probes and ligands for studying biological targets and pathways.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring complex, fluorinated heterocycles.

Basic Information

Product Name	1-(3-Fluoro-5-Trifluoromethylpyridin-2-Yl)Piperazine
CAS No.	845616-81-1
Molecular Formula	C11H11F4N3
Molecular Weight	261.22 g/mol
Synonyms	2-(Piperazin-1-yl)-3-fluoro-5-(trifluoromethyl)pyridine; 3-Fluoro-5-(trifluoromethyl)-2-piperazin-1-ylpyridine; 1-(3-Fluoro-5-(trifluoromethyl)pyridin-2-yl)piperazine; 845616-81-1; 1-(3-Fluoro-5-trifluoromethyl-2-pyridinyl)piperazine
EINECS	Contact for details

Quality Control

Our 1-(3-Fluoro-5-Trifluoromethylpyridin-2-Yl)Piperazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our commitment to cGMP principles and adherence to ISO standards ensure reliable supply for your most demanding research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong acids and strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.