Description

tert-Butyl 5-Bromopyridine-2-Carboxylate 98 is a high-purity brominated pyridine derivative that serves as a versatile and critical building block in advanced organic synthesis. This compound is valued for its reactive bromine atom and protected carboxylate group, enabling precise molecular construction. It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating complex molecules and active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the pyridine core for biological activity.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the construction of organic electronic materials, such as those used in OLEDs and conductive polymers.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Academic & R&D Laboratories: Used in medicinal chemistry programs for structure-activity relationship (SAR) studies and library synthesis.

Basic Information

Product Name	tert-Butyl 5-Bromopyridine-2-Carboxylate 98
CAS No.	845306-08-3
Molecular Formula	C10H12BrNO2
Molecular Weight	258.11 g/mol
Synonyms	5-Bromo-2-pyridinecarboxylic acid tert-butyl ester; tert-Butyl 5-bromopicolinate; 2-Pyridinecarboxylic acid, 5-bromo-, 1,1-dimethylethyl ester; 5-Bromopicolinic acid tert-butyl ester; 845306-08-3; TBBC; 5-Bromo-2-(tert-butoxycarbonyl)pyridine
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-Bromopyridine-2-Carboxylate 98 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are available upon request, supporting compliance in cGMP and ISO 9001 environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.