Description

(8-Trifluoromethyl-Quinolin-4-Yloxy)-Acetic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its unique quinoline core functionalized with a trifluoromethyl group and an acetic acid side chain. This compound matters for its critical role as a versatile building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular modifications. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries engaged in drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Research: Serves as a structural motif in the development of new-generation herbicides and pesticides, leveraging the biological activity of the quinoline scaffold.
• Ligand & Catalyst Development: Utilized in organometallic chemistry for creating novel ligands and catalysts due to its electron-withdrawing trifluoromethyl group.
• Fluorine Chemistry Studies: An important compound for research into the effects of fluorine substitution on the pharmacokinetic and physicochemical properties of molecules.
• Material Science: Investigated for potential use in the synthesis of organic electronic materials and advanced polymers.

Basic Information

Product Name	(8-Trifluoromethyl-Quinolin-4-Yloxy)-Acetic Acid
CAS No.	845264-81-5
Molecular Formula	C₁₂H₈F₃NO₃
Molecular Weight	271.19 g/mol
Synonyms	2-[(8-Trifluoromethyl-4-quinolyl)oxy]acetic acid; 4-Quinolinol, 8-(trifluoromethyl)-, O-acetate; (8-(Trifluoromethyl)quinolin-4-yloxy)acetic acid; 8-Trifluoromethyl-4-quinolyloxyacetic acid; Acetic acid, (8-(trifluoromethyl)-4-quinolinyl)oxy]-; 4-Quinolyloxyacetic acid, 8-trifluoromethyl-; TFQA
EINECS	Contact for details

Quality Control

Our (8-Trifluoromethyl-Quinolin-4-Yloxy)-Acetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and production. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and organic solvents. Due to its light-sensitive nature, containers should be kept in secondary packaging or amber glass.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.