Description

Benzyl 3-Fluoro-4-Oxopiperidine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its piperidinone core and fluorine substituent. This compound is critical for medicinal chemistry research and development, serving as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers targeting therapeutic areas such as central nervous system (CNS) disorders and oncology.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of complex drug candidates, particularly those targeting protease and kinase enzymes.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Synthesis: Employed in the development and scale-up production of Active Pharmaceutical Ingredients (APIs) with fluorinated piperidine motifs.
• Chemical Biology Probes: Serves as a building block for creating specialized molecular probes used to study biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity fluorinated heterocycles.

Basic Information

Product Name	Benzyl 3-Fluoro-4-Oxopiperidine-1-Carboxylate
CAS No.	845256-59-9
Molecular Formula	C13H14FNO3
Molecular Weight	251.25 g/mol
Synonyms	1-Carbobenzyloxy-3-fluoro-4-piperidinone; Benzyl 3-fluoro-4-oxo-1-piperidinecarboxylate; 3-Fluoro-1-[(phenylmethoxy)carbonyl]-4-piperidinone; 3-Fluoro-4-oxopiperidine-1-carboxylic acid benzyl ester; 1-N-CBZ-3-fluoro-4-piperidinone; 3-Fluoro-1-Cbz-4-piperidone; 3-Fluoro-4-piperidinone-1-carboxylic acid benzyl ester
EINECS	Contact for details

Quality Control

Our Benzyl 3-Fluoro-4-Oxopiperidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and a Certificate of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents and bases. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.