Description

2-Chloro-1-[[2-(Trimethylsilanyl)Ethoxy]Methyl]-Benzimidazole is a sophisticated organosilicon-protected benzimidazole derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its primary value lies in its role as a protected precursor for the synthesis of complex pharmaceutical molecules and high-performance materials, offering chemists a strategic handle for selective deprotection and further functionalization. This compound is essential for R&D and production teams in the pharmaceutical, agrochemical, and specialty chemical industries, where it is used to build novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel benzimidazole-based active pharmaceutical ingredients (APIs), including antiviral and anticancer agents.
• Agrochemical Synthesis: Used in the development of next-generation fungicides and herbicides that leverage the benzimidazole scaffold for enhanced biological activity.
• Material Science Research: Acts as a monomer or functionalization agent in the creation of specialty polymers and advanced organic materials with tailored properties.
• Chemical Biology & Proteomics: Employed as a reagent for modifying peptides or creating activity-based probes to study enzyme function.
• Academic & Industrial R&D: A valuable tool for medicinal chemists and process development scientists exploring new synthetic routes and reaction methodologies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of client-specific target molecules under cGMP or research-grade conditions.

Basic Information

Product Name	2-Chloro-1-[[2-(Trimethylsilanyl)Ethoxy]Methyl]-Benzimidazole
CAS No.	841200-42-8
Molecular Formula	C13H19ClN2OSi
Molecular Weight	282.84 g/mol
Synonyms	2-Chloro-1-[(2-(trimethylsilyl)ethoxy)methyl]-1H-benzimidazole; 1H-Benzimidazole, 2-chloro-1-[[2-(trimethylsilyl)ethoxy]methyl]-; 2-Chloro-1-((2-(trimethylsilyl)ethoxy)methyl)benzimidazole; 2-Chloro-1-((2-trimethylsilylethoxy)methyl)benzimidazole; 2-Chloro-1-[(2-trimethylsilylethoxy)methyl]benzimidazole; 2-Chloro-1-[[2-(trimethylsilyl)ethoxy]methyl]benzimidazole; SEM-protected 2-chlorobenzimidazole; Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and development. Every batch is characterized using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry to confirm identity, purity, and consistency. Certificates of Analysis (COA) are provided with each shipment, detailing batch-specific results. We adhere to a quality management system and can supply material suitable for use under cGMP guidelines for pharmaceutical development upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (HPLC)	≥ 99.0% (High Purity Grade)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.