Description

1H-Isoindole-1,3(2H)-Dione, 5-Chloro-2-(2,6-Dioxo-3-Piperidinyl)- is a high-purity pharmaceutical intermediate and building block of significant importance in modern organic synthesis. This compound serves as a critical precursor in the development of novel active pharmaceutical ingredients (APIs), particularly in targeted therapeutic areas. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the synthesis of complex molecules for drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates and active pharmaceutical ingredients (APIs).
• Proteolysis Targeting Chimera (PROTAC) Development: Used in the construction of linker and warhead components for targeted protein degradation therapeutics.
• Cereblon (CRBN) E3 Ligase Modulator Research: Serves as a core structural motif in the development of immunomodulatory imide drugs (IMiDs) and related compounds.
• Medicinal Chemistry & Drug Discovery: Employed in structure-activity relationship (SAR) studies and the creation of focused libraries for high-throughput screening.
• Chemical Biology Probe Synthesis: Utilized to create molecular tools for studying cellular pathways and protein function.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of client-specific target molecules under cGMP or research-grade conditions.

Basic Information

Product Name	1H-Isoindole-1,3(2H)-Dione, 5-Chloro-2-(2,6-Dioxo-3-Piperidinyl)-
CAS No.	835616-62-1
Molecular Formula	C13H9ClN2O4
Molecular Weight	292.67 g/mol
Synonyms	5-Chloro-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; 3-(5-Chloro-1,3-dioxoisoindolin-2-yl)piperidine-2,6-dione; 5-Chlorothalidomide; 5-Cl-Thalidomide; 5-Chloro-2-(2,6-dioxo-3-piperidyl)phthalimide; 5-Chloro-2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione; 5-Chloro-3-(2,6-dioxopiperidin-3-yl)phthalimide
EINECS	Contact for details

Quality Control

Our 1H-Isoindole-1,3(2H)-Dione, 5-Chloro-2-(2,6-Dioxo-3-Piperidinyl)- is manufactured under strict quality management systems. We offer material suitable for research and development, with specifications tailored to client requirements. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. Certificates of Origin and Material Safety Data Sheets (MSDS/SDS) are provided to ensure full regulatory and safety compliance for global supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent moisture absorption. Recommended storage temperature is 2-8°C for extended stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.