Description

4-Cyclopropyl-6-Difluoromethyl-2-Mercapto-Nicotinonitrile is a high-value, multi-functional heterocyclic building block featuring a reactive mercapto group and a difluoromethyl substituent. This compound is critical for research and development in advanced organic synthesis, enabling the creation of novel molecular architectures. It is primarily sought after by pharmaceutical and agrochemical R&D teams for the synthesis of active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, leveraging the difluoromethyl and cyclopropyl motifs for enhanced bioactivity.
• Material Science Research: Serves as a building block for functionalized polymers and advanced organic materials.
• Chemical Biology Probes: Utilized in the design of molecular probes and inhibitors for studying enzyme function and biological pathways.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for bespoke client projects requiring complex pyridine derivatives.

Basic Information

Product Name	4-Cyclopropyl-6-Difluoromethyl-2-Mercapto-Nicotinonitrile
CAS No.	832741-18-1
Molecular Formula	C10H8F2N2S
Molecular Weight	226.25 g/mol
Synonyms	2-Mercapto-4-cyclopropyl-6-(difluoromethyl)nicotinonitrile; 4-Cyclopropyl-6-(difluoromethyl)-2-mercaptonicotinonitrile; 2-Mercapto-4-cyclopropyl-6-(difluoromethyl)-3-pyridinecarbonitrile; 3-Pyridinecarbonitrile, 4-cyclopropyl-6-(difluoromethyl)-2-mercapto-; 832741-18-1; 4-Cyclopropyl-6-difluoromethyl-2-mercaptonicotinonitrile
EINECS	Contact for details

Quality Control

Our 4-Cyclopropyl-6-Difluoromethyl-2-Mercapto-Nicotinonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to handle and store under an inert atmosphere for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.