Description

6-[Chloro(Difluoro)Methyl]-4-Methyl-2-Thioxo-1,2-Dihydropyridine-3-Carbonitrile is a high-purity, advanced pharmaceutical intermediate characterized by its unique halogenated pyridine-thione structure. This compound is of significant commercial value for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex molecular architectures. It is primarily sought by research institutions and manufacturers in the pharmaceutical and agrochemical industries engaged in developing next-generation small molecule drugs and crop protection agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of complex heterocyclic APIs, especially for central nervous system (CNS) and anti-infective drug candidates.
• Agrochemical Research: Serves as a versatile scaffold for developing new herbicides and fungicides, leveraging the biological activity of the thioxo-dihydropyridine core.
• Chemical Synthesis Building Block: Used in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis due to its reactive chloro-difluoromethyl and nitrile functional groups.
• Material Science Research: Investigated as a potential monomer or additive for creating specialty polymers with unique electronic or surface properties.

Basic Information

Product Name	6-[Chloro(Difluoro)Methyl]-4-Methyl-2-Thioxo-1,2-Dihydropyridine-3-Carbonitrile
CAS No.	832740-39-3
Molecular Formula	C9H5ClF2N2S
Molecular Weight	246.66 g/mol
Synonyms	6-(Chlorodifluoromethyl)-4-methyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile; 4-Methyl-6-(chlorodifluoromethyl)-2-thioxo-1,2-dihydropyridine-3-carbonitrile; 3-Cyano-6-(chlorodifluoromethyl)-4-methyl-2(1H)-pyridinethione; 832740-39-3; 6-(Chlorodifluoromethyl)-4-methyl-2-thioxo-1,2-dihydro-3-pyridinecarbonitrile
EINECS	Contact for details

Quality Control

Our 6-[Chloro(Difluoro)Methyl]-4-Methyl-2-Thioxo-1,2-Dihydropyridine-3-Carbonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR, to ensure it meets the high standards required for pharmaceutical R&D and scale-up. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.