Description

2-Difluoromethoxy-4,6-Dimethyl-Nicotinonitrile is a high-purity, advanced pharmaceutical intermediate characterized by its unique difluoromethoxy and nitrile-substituted pyridine core structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular modifications. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of next-generation small molecule drugs, agrochemicals, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Research: Serves as a precursor for developing novel herbicides and pesticides with enhanced efficacy and selectivity.
• Material Science: Used in the research and development of specialty polymers and liquid crystals due to its stable heterocyclic structure.
• Chemical Synthesis: Employed in organic synthesis for introducing the difluoromethoxy and cyano functional groups into more complex molecular architectures.
• Life Science Reagents: Utilized in the preparation of biochemical probes and tool compounds for biological pathway studies.

Basic Information

Product Name	2-Difluoromethoxy-4,6-Dimethyl-Nicotinonitrile
CAS No.	832737-66-3
Molecular Formula	C9H8F2N2O
Molecular Weight	198.17 g/mol
Synonyms	2-(Difluoromethoxy)-4,6-dimethylnicotinonitrile; 4,6-Dimethyl-2-(difluoromethoxy)nicotinonitrile; Nicotinonitrile, 2-(difluoromethoxy)-4,6-dimethyl-; 832737-66-3; 2-Difluoromethoxy-4,6-dimethyl-3-cyanopyridine
EINECS	Contact for details

Quality Control

Our 2-Difluoromethoxy-4,6-Dimethyl-Nicotinonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids, strong bases, and oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.