Description

5-Bromo-1-(difluoromethyl)pyridin-2(1H)-one is a high-value, halogenated pyridone derivative serving as a critical synthetic intermediate. Its unique structure, featuring both bromine and difluoromethyl substituents, makes it an essential building block for constructing complex molecules with tailored properties. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the difluoromethyl group can enhance metabolic stability and bioavailability.
• Material Science: Serves as a monomer or functionalizing agent in the creation of advanced polymers and liquid crystals with specific electronic or optical properties.
• Chemical Synthesis: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic substitution reactions to introduce the pyridone core into more complex molecular architectures.
• Fluorine Chemistry: Acts as a valuable scaffold for studying the effects of fluorine substitution on biological activity and physicochemical parameters in drug discovery.

Basic Information

Item	Details
Product Name	5-Bromo-1-(difluoromethyl)pyridin-2(1H)-one
CAS No.	832735-61-2
Molecular Formula	C7H4BrF2NO
Molecular Weight	236.01 g/mol
Synonyms	5-Bromo-1-(difluoromethyl)-2(1H)-pyridinone; 5-Bromo-1-(difluoromethyl)-1,2-dihydropyridin-2-one; 5-Bromo-1-(difluoromethyl)-2-pyridone; 2(1H)-Pyridinone, 5-bromo-1-(difluoromethyl)-; 1-(Difluoromethyl)-5-bromo-2(1H)-pyridinone; 5-Bromo-1-difluoromethyl-1H-pyridin-2-one
EINECS	Contact for details

Quality Control

Our 5-Bromo-1-(difluoromethyl)pyridin-2(1H)-one is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.