Description

4-Bromo-2-(Difluoromethoxy)Pyridine is a high-purity halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both bromine and difluoromethoxy substituents, makes it an invaluable intermediate for introducing specific functionalities into target molecules. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon in the development of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoromethoxy group can enhance biological activity and metabolic stability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the synthesis of specialty polymers, liquid crystals, and electronic materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form complex biaryl systems.
• Medicinal Chemistry Research: A versatile scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Fluorine Chemistry: The difluoromethoxy group provides a metabolically stable isostere for methoxy or hydroxy groups, crucial in drug design to improve pharmacokinetic properties.

Basic Information

Product Name	4-Bromo-2-(Difluoromethoxy)Pyridine
CAS No.	832735-56-5
Molecular Formula	C6H4BrF2NO
Molecular Weight	224.00 g/mol
Synonyms	2-(Difluoromethoxy)-4-bromopyridine; 4-Bromo-2-(difluoromethoxy)pyridine; Pyridine, 4-bromo-2-(difluoromethoxy)-; 4-Bromo-2-difluoromethoxypyridine
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-(Difluoromethoxy)Pyridine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring GMP-grade intermediates and materials for regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to prevent moisture absorption and contamination. Store away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.