Description

tert-Butyl (5-Ethynylpyridin-2-Yl)Carbamate is a high-purity, advanced pharmaceutical intermediate featuring a pyridine core with an ethynyl functional group. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules through versatile cross-coupling reactions. It is primarily utilized by research institutions and pharmaceutical manufacturers developing targeted therapies, including kinase inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for oncology and anti-inflammatory targets.
• Kinase Inhibitor Synthesis: Serves as a crucial precursor in constructing sophisticated kinase inhibitor scaffolds for targeted cancer therapies.
• Cross-Coupling Reactions: The ethynyl group enables efficient Sonogashira and other palladium-catalyzed cross-coupling reactions to create complex molecular architectures.
• Chemical Biology Probes: Used in the development of chemical probes for studying protein function and biological pathways in drug discovery.
• Agrochemical Research: Employed as an intermediate in the synthesis of advanced crop protection agents and herbicides.
• Material Science: Potential building block for functionalized polymers and advanced organic electronic materials.

Basic Information

Product Name	tert-Butyl (5-Ethynylpyridin-2-Yl)Carbamate
CAS No.	832698-01-8
Molecular Formula	C12H14N2O2
Molecular Weight	218.25 g/mol
Synonyms	2-[(tert-Butoxycarbonyl)amino]-5-ethynylpyridine; 5-Ethynyl-2-pyridinamine, N-BOC-protected; tert-Butyl N-(5-ethynyl-2-pyridinyl)carbamate; BOC-5-Ethynyl-2-aminopyridine; N-Boc-5-ethynylpyridin-2-amine; 5-Ethynylpyridin-2-amine, N-Boc derivative; Carbamic acid, N-(5-ethynyl-2-pyridinyl)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl (5-Ethynylpyridin-2-Yl)Carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP standards for pharmaceutical intermediates, ensuring reliability for your critical research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.