Description

Valategrast Hydrochloride is a high-purity, small-molecule pharmaceutical intermediate and active ingredient. This compound is primarily valued for its role as a potent and selective antagonist of the α4β1 integrin (VLA-4), a key target in inflammatory and autoimmune pathways. It is essential for research and development within the pharmaceutical and biotechnology sectors, particularly for programs focused on respiratory and inflammatory conditions. The material is supplied as Valategrast Hydrochloride CAS NO 828271-96-1 to ensure precise identification and sourcing for critical applications.

Application

• Pharmaceutical Active Ingredient (API): Serves as the core active component in the formulation of investigational new drugs targeting VLA-4.
• Preclinical & Clinical Research: Used in in vitro and in vivo studies to investigate mechanisms of inflammation, asthma, and multiple sclerosis.
• Reference Standard: Employed as an analytical standard for method development, validation, and quality control testing in laboratory settings.
• Process Chemistry & Scale-Up: A key intermediate for chemical synthesis during process optimization and pilot-scale manufacturing campaigns.
• Biochemical Assay Development: Utilized in high-throughput screening (HTS) and binding assays to identify and characterize new therapeutic candidates.

Basic Information

Product Name	Valategrast Hydrochloride
CAS No.	828271-96-1
Molecular Formula	C₂₉H₃₈ClN₅O₅
Molecular Weight	572.09 g/mol
Synonyms	N-[3-({[5-(4-Chlorophenyl)-2-furyl]methyl}sulfanyl)-2-hydroxy-1-(1H-1,2,4-triazol-1-ylmethyl)propyl]-3-methyl-L-valinamide Hydrochloride; R-411; R 411; UNII-9W6H8L6K2P; Valategrast HCl; (2S)-N-[(1S)-3-({[5-(4-Chlorophenyl)-2-furyl]methyl}sulfanyl)-2-hydroxy-1-[(1H-1,2,4-triazol-1-yl)methyl]propyl]-3-methyl-L-valinamide Hydrochloride
EINECS	Contact for details

Quality Control

Our Valategrast Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and stringent control of residual solvents and impurities to meet pharmaceutical-grade standards. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with your research or development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccant in the container.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.