Description

Pentadecanoic Acid n-Hydroxysuccinimide Ester is a high-purity, activated fatty acid derivative designed for efficient bioconjugation and labeling applications. This compound is a critical reagent for researchers and manufacturers requiring stable amide bond formation with primary amines under mild conditions. It is essential for professionals in pharmaceutical development, proteomics, and advanced materials science who need reliable, high-quality building blocks for synthesizing lipidated peptides, proteins, and other biomolecules.

Application

• Bioconjugation Reagent: For the site-specific labeling of peptides, proteins, and antibodies with pentadecanoic acid (C15:0) chains.
• Proteomics Research: Used in the synthesis of lipidated peptide standards and probes for studying protein lipidation, trafficking, and membrane association.
• Pharmaceutical Intermediates: Serves as a key building block in the development of novel drug candidates, including lipid-conjugated therapeutics and diagnostic agents.
• Biomaterial Functionalization: Enables the covalent attachment of fatty acid chains to polymers, nanoparticles, and surfaces to modify hydrophobicity and biocompatibility.
• Chemical Biology Tools: Facilitates the creation of activity-based probes and pull-down reagents for target identification and validation in lipid metabolism pathways.
• Standards Synthesis: Critical for preparing internal standards and calibrants used in mass spectrometry-based lipidomics and metabolomics analyses.

Basic Information

Product Name	Pentadecanoic Acid n-Hydroxysuccinimide Ester
CAS No.	823780-38-7
Molecular Formula	C19H33NO4
Molecular Weight	339.47 g/mol
Synonyms	Pentadecanoic Acid N-Hydroxysuccinimide Ester; Pentadecanoic Acid NHS Ester; N-Hydroxysuccinimide Pentadecanoate; C15:0 Fatty Acid NHS Ester; 15:0 NHS Ester; NSC 113927; Pentadecanoic Acid 2,5-Dioxopyrrolidin-1-yl Ester; 1-[(Pentadecanoyl)oxy]-2,5-pyrrolidinedione
EINECS	Contact for details

Quality Control

Our Pentadecanoic Acid n-Hydroxysuccinimide Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent hydrolysis of the active ester. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Melting Point	Contact for details
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.