Description

Methyl 8-Bromo-2,3-Dihydrobenzo[B][1,4]Dioxine-5-Carboxylate is a high-purity, synthetically valuable brominated benzodioxine derivative. This compound serves as a crucial advanced pharmaceutical intermediate and a versatile building block for organic synthesis, enabling the development of novel active molecules. It is primarily required by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex heterocyclic frameworks.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of potential drug candidates targeting central nervous system (CNS) disorders, cardiovascular diseases, and anti-inflammatory agents.
• Agrochemical Research: Building block for developing novel herbicides, fungicides, and insecticides with modified activity profiles.
• Material Science: Monomer or functional additive for creating specialized polymers, liquid crystals, or organic electronic materials.
• Chemical Synthesis: Versatile substrate for cross-coupling reactions (e.g., Suzuki, Stille), nucleophilic substitutions, and further functionalization of the benzodioxine core.
• Academic & R&D: Reference standard and starting material for methodological studies in organic and medicinal chemistry.

Basic Information

Product Name	Methyl 8-Bromo-2,3-Dihydrobenzo[B][1,4]Dioxine-5-Carboxylate
CAS No.	823225-66-7
Molecular Formula	C10H9BrO4
Molecular Weight	273.08 g/mol
Synonyms	8-Bromo-2,3-dihydro-1,4-benzodioxine-5-carboxylic acid methyl ester; Methyl 8-bromo-2,3-dihydro-1,4-benzodioxine-5-carboxylate; 5-Methoxycarbonyl-8-bromo-2,3-dihydro-1,4-benzodioxin; 8-Bromo-2,3-dihydrobenzo[b][1,4]dioxine-5-carboxylic acid methyl ester; 823225-66-7; Methyl 8-bromodihydrobenzo-1,4-dioxine-5-carboxylate
EINECS	Contact for details

Quality Control

Our production of Methyl 8-Bromo-2,3-Dihydrobenzo[B][1,4]Dioxine-5-Carboxylate adheres to stringent in-process controls and final batch analysis to ensure consistent purity and identity. Every lot is characterized by advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment, supporting cGMP-compliant development workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and bases. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.