Description

3-Bromo-5-Chloro-2-(Trifluoromethyl)Pyridine is a high-value, multi-halogenated pyridine derivative that serves as a critical building block in advanced chemical synthesis. Its unique structure, featuring bromine, chlorine, and trifluoromethyl substituents, makes it an indispensable intermediate for introducing specific steric and electronic properties into target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the stability imparted by the halogen and fluorine groups.
• Material Science Research: Serves as a monomer or functionalization agent for creating specialty polymers and liquid crystals with tailored properties.
• Chemical Biology: Employed as a probe or labeling reagent due to its reactive halogen sites for bioconjugation.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	3-Bromo-5-Chloro-2-(Trifluoromethyl)Pyridine
CAS No.	823222-22-6
Molecular Formula	C6H2BrClF3N
Molecular Weight	260.44 g/mol
Synonyms	2-(Trifluoromethyl)-3-bromo-5-chloropyridine; 5-Chloro-3-bromo-2-(trifluoromethyl)pyridine; 3-Bromo-5-chloro-2-trifluoromethylpyridine; Pyridine, 3-bromo-5-chloro-2-(trifluoromethyl)-; 823222-22-6; 3-Bromo-5-chloro-α,α,α-trifluoro-2-picoline
EINECS	Contact for details

Quality Control

Every batch of 3-Bromo-5-Chloro-2-(Trifluoromethyl)Pyridine undergoes rigorous analytical testing to ensure it meets the high-purity standards required for sensitive synthetic applications. Our quality assurance protocol includes identity confirmation, purity assay, and detailed impurity profiling. A comprehensive Certificate of Analysis (COA) documenting all test results is provided with each shipment to guarantee traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.