Description

2-Bromo-5-(Trifluoromethyl)Isonicotinic Acid is a high-value, multi-functional heterocyclic building block characterized by its bromine and trifluoromethyl substituents. This compound is essential for medicinal chemistry and agrochemical research, where it serves as a key intermediate for introducing specific pharmacophores and enhancing molecular properties like lipophilicity and metabolic stability. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced material sectors for synthesizing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of potential drug candidates, particularly for kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used to construct advanced active ingredients for crop protection products, leveraging the bioactivity of the pyridine core and halogenated motifs.
• Material Science Research: Serves as a building block for creating specialized ligands, organic semiconductors, or metal-organic frameworks (MOFs).
• Chemical Biology Probes: Employed in the development of molecular probes and tags for studying biological processes and target engagement.
• Custom Synthesis & Contract Manufacturing: A starting material for custom synthesis projects and scale-up processes under cGMP or ISO standards.

Basic Information

Product Name	2-Bromo-5-(Trifluoromethyl)Isonicotinic Acid
CAS No.	823222-03-3
Molecular Formula	C7H3BrF3NO2
Molecular Weight	269.99 g/mol
Synonyms	2-Bromo-5-(trifluoromethyl)pyridine-4-carboxylic acid; 4-Pyridinecarboxylic acid, 2-bromo-5-(trifluoromethyl)-; 2-Bromo-5-trifluoromethylisonicotinic acid; 2-Bromo-5-(trifluoromethyl)-4-pyridinecarboxylic acid; 2-Bromo-5-(trifluoromethyl)nicotinic acid (common misnomer); 2-Bromo-5-trifluoromethyl-4-pyridinecarboxylic acid; BTFI Acid; 823222-03-3
EINECS	Contact for details

Quality Control

Our 2-Bromo-5-(Trifluoromethyl)Isonicotinic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and relevant industry standards for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.