Description

5-Chloro-2-(Trifluoromethyl)Nicotinic Acid is a high-value, multi-functional chemical building block characterized by its unique trifluoromethyl and chloro-substituted pyridine core. This compound is essential for synthesizing advanced molecules, where its structure imparts desirable properties like metabolic stability and enhanced lipophilicity. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science Research: Serves as a building block for creating specialty polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing properties.
• Chemical Biology & Proteomics: Employed as a versatile scaffold for designing molecular probes, enzyme inhibitors, and labeled compounds for diagnostic and research applications.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	5-Chloro-2-(Trifluoromethyl)Nicotinic Acid
CAS No.	823222-02-2
Molecular Formula	C7H3ClF3NO2
Molecular Weight	225.55 g/mol
Synonyms	5-Chloro-2-(trifluoromethyl)pyridine-3-carboxylic acid; 3-Carboxy-5-chloro-2-trifluoromethylpyridine; 2-Trifluoromethyl-5-chloronicotinic acid; 5-Chloro-2-trifluoromethylnicotinic acid; 5-Chloro-2-(trifluoromethyl)-3-pyridinecarboxylic acid; Nicotinic acid, 5-chloro-2-(trifluoromethyl)-; 3-Pyridinecarboxylic acid, 5-chloro-2-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 5-Chloro-2-(Trifluoromethyl)Nicotinic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and organic solvents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.