Description

5-Chloro-2-(Trifluoromethyl)Isonicotinic Acid is a high-value fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, combining a halogenated pyridine core with a trifluoromethyl group, makes it indispensable for creating novel compounds with enhanced biological activity and physicochemical properties. This intermediate is primarily sought after by pharmaceutical and agrochemical research and development teams for the synthesis of active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new active pharmaceutical ingredients (APIs), particularly in antiviral, antibacterial, and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group can improve efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in catalytic systems and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of functionalized polymers and advanced organic electronic materials.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	5-Chloro-2-(Trifluoromethyl)Isonicotinic Acid
CAS No.	823222-01-1
Molecular Formula	C7H3ClF3NO2
Molecular Weight	225.55 g/mol
Synonyms	5-Chloro-2-(trifluoromethyl)pyridine-4-carboxylic acid; 4-Pyridinecarboxylic acid, 5-chloro-2-(trifluoromethyl)-; 5-Chloro-2-trifluoromethylisonicotinic acid; 5-Chloro-2-(trifluoromethyl)isonicotinate; 823222-01-1; 5-Chloro-2-(trifluoromethyl)-4-pyridinecarboxylic acid
EINECS	Contact for details

Quality Control

Our 5-Chloro-2-(Trifluoromethyl)Isonicotinic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, confirming compliance with customer specifications and industry standards for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.