Description

2-Pyridinecarboxylic Acid, 6-Chloro-4-(Trifluoromethyl)- is a high-value, multi-functional heterocyclic building block characterized by its pyridine core substituted with chloro and trifluoromethyl groups. This compound matters for its role as a critical intermediate in the synthesis of advanced agrochemicals and active pharmaceutical ingredients (APIs), where its unique halogenated and fluorinated structure imparts desirable biological activity and metabolic stability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, leveraging the bioactivity of the trifluoromethylpyridine moiety.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in metal-catalyzed cross-coupling reactions.
• Material Science Research: Employed in the development of organic electronic materials and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized to create molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis projects requiring complex, fluorinated heterocycles.

Basic Information

Product Name	2-Pyridinecarboxylic Acid, 6-Chloro-4-(Trifluoromethyl)-
CAS No.	823222-00-0
Molecular Formula	C7H3ClF3NO2
Molecular Weight	225.55 g/mol
Synonyms	6-Chloro-4-(trifluoromethyl)picolinic acid; 6-Chloro-4-(trifluoromethyl)pyridine-2-carboxylic acid; 2-Pyridinecarboxylic acid, 6-chloro-4-(trifluoromethyl)-; 4-(Trifluoromethyl)-6-chloropicolinic acid; 6-Chloro-4-trifluoromethylpicolinic acid; 6-Chloro-α,α,α-trifluoro-4-picolinic acid
EINECS	Contact for details

Quality Control

Our 2-Pyridinecarboxylic Acid, 6-Chloro-4-(Trifluoromethyl)- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container must be kept tightly sealed due to the compound's sensitivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.