Description

3-Bromo-5-Chloro-2-Iodopyridine is a highly functionalized halogenated pyridine derivative, serving as a critical multi-purpose building block in advanced organic synthesis. Its value lies in the strategic placement of three distinct halogens, which offer orthogonal reactivity for sequential cross-coupling and functional group transformations. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to construct complex heterocyclic scaffolds for active ingredients and materials science applications.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used to develop advanced fungicides, herbicides, and insecticides with complex pyridine-based structures.
• Material Science: Serves as a building block for creating functionalized ligands, organic semiconductors, and liquid crystal materials.
• Cross-Coupling Reactions: The bromo, chloro, and iodo substituents allow for selective Suzuki, Stille, and Negishi coupling reactions to introduce diverse aryl and alkyl groups.
• Chemical Research: A versatile reagent in academic and industrial R&D for exploring new synthetic methodologies and heterocyclic chemistry.
• Ligand Preparation: Useful for synthesizing polydentate ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	3-Bromo-5-Chloro-2-Iodopyridine
CAS No.	823221-97-2
Molecular Formula	C5H2BrClIN
Molecular Weight	318.34 g/mol
Synonyms	2-Iodo-3-bromo-5-chloropyridine; 5-Chloro-3-bromo-2-iodopyridine; 3-Bromo-5-chloro-2-iodopyridine; Pyridine, 3-bromo-5-chloro-2-iodo-; 823221-97-2; 2-Iodo-3,5-dihalopyridine; 3,5-Dihalo-2-iodopyridine
EINECS	Contact for details

Quality Control

Our 3-Bromo-5-Chloro-2-Iodopyridine is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality systems are designed to meet the stringent requirements of cGMP and ISO standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.