Description

Pyridine, 3-Chloro-2-Iodo-6-(Trifluoromethyl)- is a highly functionalized halogenated pyridine derivative, serving as a critical multi-purpose building block in advanced organic synthesis. Its unique structure, featuring chlorine, iodine, and trifluoromethyl substituents, provides distinct reactivity and physicochemical properties for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries who require precise, high-purity intermediates for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Ligand & Catalyst Development: Serves as a sophisticated scaffold for creating novel ligands in transition metal catalysis and organocatalysis, enabling challenging chemical transformations.
• Material Science & OLEDs: Employed in the synthesis of electron-transport materials and host compounds for organic light-emitting diodes (OLEDs) due to its electron-deficient aromatic core.
• Fluorinated Compound Library: A valuable building block for medicinal chemistry and discovery chemistry programs focused on expanding fluorinated compound libraries to improve drug-like properties.
• Cross-Coupling Reactions: The iodine and chlorine substituents make it an excellent substrate for sequential palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create highly decorated heterocycles.

Basic Information

Product Name	Pyridine, 3-Chloro-2-Iodo-6-(Trifluoromethyl)-
CAS No.	823221-96-1
Molecular Formula	C6H2ClF3IN
Molecular Weight	321.44 g/mol
Synonyms	3-Chloro-2-iodo-6-(trifluoromethyl)pyridine; 2-Iodo-3-chloro-6-(trifluoromethyl)pyridine; 6-(Trifluoromethyl)-3-chloro-2-iodopyridine; 3-Chloro-2-iodo-6-trifluoromethylpyridine; Pyridine, 3-chloro-2-iodo-6-(trifluoromethyl)-; 823221-96-1; 3-Chloro-2-iodo-α,α,α-trifluoro-6-picoline
EINECS	Contact for details

Quality Control

Our production of Pyridine, 3-Chloro-2-Iodo-6-(Trifluoromethyl)- adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical characterization, including HPLC for purity assessment and NMR (1H, 13C, 19F) and Mass Spectrometry for structural confirmation. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research and development specifications. Our quality system is designed to support cGMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. Store away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.