Description

1-[4-Amino-7-(3-Hydroxypropyl)-5-(4-Methylphenyl)-7H-Pyrrolo[2,3-D]Pyrimidin-6-Yl]-2-Fluoroethanone is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. Its complex pyrrolopyrimidine core structure makes it a critical building block in the synthesis of targeted therapeutic agents. This compound is primarily utilized by pharmaceutical R&D departments and fine chemical manufacturers engaged in developing novel small-molecule drugs.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of kinase inhibitors and other targeted cancer therapies.
• Biochemical Research: Used as a reference standard or probe molecule in enzymatic and cellular pathway studies.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize drug candidate potency and selectivity.
• API Development: Integrated into the synthetic route for Active Pharmaceutical Ingredients (APIs) under current Good Manufacturing Practice (cGMP) conditions.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for clinical trial materials.

Basic Information

Item	Detail
Product Name	1-[4-Amino-7-(3-Hydroxypropyl)-5-(4-Methylphenyl)-7H-Pyrrolo[2,3-D]Pyrimidin-6-Yl]-2-Fluoroethanone
CAS No.	821794-92-7
Molecular Formula	C18H19FN4O2
Molecular Weight	342.37 g/mol
Synonyms	2-Fluoro-1-[4-amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)pyrrolo[2,3-d]pyrimidin-6-yl]ethanone; 1-[4-Amino-7-(3-hydroxypropyl)-5-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanone; 821794-92-7; 6-Acetyl-4-amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidine-2-fluoro derivative
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality management systems. Every batch is characterized and tested using advanced analytical techniques including HPLC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support development and commercial projects with material suitable for research use through to cGMP-grade manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. Long-term storage under an inert atmosphere (e.g., nitrogen or argon) is recommended for optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.