Description

3-Bromo-2-Chloro-4-Trimethylsilanyl-Pyridine is a high-purity, organosilicon-substituted pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique halogenated and silylated structure makes it an invaluable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, catalyst development, and material science.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and antiviral drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where its halogenated pyridine core is a common structural motif.
• Ligand and Catalyst Precursor: Serves as a starting material for synthesizing specialized nitrogen-containing ligands for transition metal catalysis.
• Material Science Research: Employed in the development of organic electronic materials, such as charge-transport layers or molecular semiconductors.
• Chemical Biology Probes: Utilized to create tagged or functionalized molecules for studying biological systems and protein interactions.
• Custom Synthesis and Contract Manufacturing: A vital component for fine chemical manufacturers offering bespoke synthesis services to clients in R&D.

Basic Information

Product Name	3-Bromo-2-Chloro-4-Trimethylsilanyl-Pyridine
CAS No.	821773-92-6
Molecular Formula	C9H13BrClNSi
Molecular Weight	278.65 g/mol
Synonyms	3-Bromo-2-chloro-4-(trimethylsilyl)pyridine; 4-Trimethylsilyl-3-bromo-2-chloropyridine; 2-Chloro-3-bromo-4-trimethylsilylpyridine; Pyridine, 3-bromo-2-chloro-4-(trimethylsilyl)-; 821773-92-6; 3-Br-2-Cl-4-TMS-Pyridine
EINECS	Contact for details

Quality Control

Our 3-Bromo-2-Chloro-4-Trimethylsilanyl-Pyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) for every shipment, supporting your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.