Description

6H-Pyrazolo[3,4-B]Pyridin-6-One,3-Cyclobutyl-1,2,4,5-Tetrahydro-4-Methyl-(9Ci) is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular scaffolds. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in drug discovery and process development for central nervous system (CNS) and oncology targets. The compound, identified by CAS No. 817641-90-0, is supplied under stringent quality control to ensure batch-to-batch consistency for sensitive synthetic applications.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel drug candidates targeting specific biological pathways.
• Drug Discovery Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization, especially for kinase inhibitors and receptor modulators.
• Chemical Biology Probes: Serves as a core scaffold for developing tool compounds to study enzyme function and cellular signaling processes.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant scale for clinical trial material production.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs for the custom synthesis of complex molecules for client projects.
• Academic Research: Used in university and institutional labs for methodological development in heterocyclic chemistry and catalysis studies.

Basic Information

Product Name	6H-Pyrazolo[3,4-B]Pyridin-6-One,3-Cyclobutyl-1,2,4,5-Tetrahydro-4-Methyl-(9Ci)
CAS No.	817641-90-0
Molecular Formula	C11H15N3O
Molecular Weight	205.26 g/mol
Synonyms	3-Cyclobutyl-4-methyl-1,2,4,5-tetrahydro-6H-pyrazolo[3,4-b]pyridin-6-one; 3-Cyclobutyl-4-methyl-1,4,5,6-tetrahydropyrazolo[3,4-b]pyridin-7-one; 817641-90-0; 6H-Pyrazolo[3,4-b]pyridin-6-one, 3-cyclobutyl-1,2,4,5-tetrahydro-4-methyl-; Pyrazolopyridinone derivative; Cyclobutyl-substituted pyrazolopyridinone; Tetrahydro-pyrazolo[3,4-b]pyridinone intermediate
EINECS	Contact for details

Quality Control

Our 6H-Pyrazolo[3,4-B]Pyridin-6-One,3-Cyclobutyl-1,2,4,5-Tetrahydro-4-Methyl-(9Ci) is manufactured under GMP-like conditions suitable for pharmaceutical research. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results from HPLC, NMR, and mass spectrometry. Our quality system is designed to meet the stringent requirements of global pharmaceutical development, and we support regulatory documentation needs for pre-clinical and clinical stage materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to atmospheric moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.