Description

2-(Chloromethyl)-4-Phenylnicotinonitrile is a specialized heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors. It is primarily needed by R&D chemists and process development scientists working on active pharmaceutical ingredients (APIs), novel crop protection agents, and other fine chemicals requiring a functionalized nicotinonitrile core.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly those targeting kinase inhibition or other biological pathways where the nicotinonitrile scaffold is relevant.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging its reactive chloromethyl and nitrile groups for further derivatization.
• Material Science Research: Serves as a precursor for the creation of specialized ligands, organic semiconductors, or metal-organic frameworks (MOFs) due to its aromatic system and functional handles.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and tool compounds for studying enzymatic activity and cellular processes.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.

Basic Information

Product Name	2-(Chloromethyl)-4-Phenylnicotinonitrile
CAS No.	817555-70-7
Molecular Formula	C13H9ClN2
Molecular Weight	228.68 g/mol
Synonyms	4-Phenyl-2-(chloromethyl)nicotinonitrile; 2-(Chloromethyl)-4-phenyl-3-pyridinecarbonitrile; 3-Cyano-2-(chloromethyl)-4-phenylpyridine; Nicotinonitrile, 2-(chloromethyl)-4-phenyl-; 4-Phenyl-2-chloromethylnicotinonitrile
EINECS	Contact for details

Quality Control

Our 2-(Chloromethyl)-4-Phenylnicotinonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). The compound may be moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.