Description

1-Boc-3-(4-Fluoro-Phenylamino)-Piperidine is a high-purity, advanced pharmaceutical intermediate featuring a protected piperidine scaffold with a fluorinated aniline substituent. This compound is critical for medicinal chemistry research and development, enabling the synthesis of novel bioactive molecules with enhanced metabolic stability and binding affinity. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors for the creation of new drug candidates targeting central nervous system (CNS) disorders and other therapeutic areas.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potential drug candidates, particularly for CNS-targeted therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to explore new chemical entities.
• Process Chemistry Development: Serves as a critical starting material or intermediate in scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Protease Inhibitor Synthesis: A potential precursor in the development of inhibitors for various enzymatic targets.
• Ligand and Receptor Studies: Employed in the design and synthesis of novel ligands for pharmacological profiling.
• Custom Synthesis and Contract Manufacturing: Supplied for bespoke organic synthesis projects in academic and industrial settings.

Basic Information

Product Name	1-Boc-3-(4-Fluoro-Phenylamino)-Piperidine
CAS No.	816468-54-9
Molecular Formula	C16H23FN2O2
Molecular Weight	294.37 g/mol
Synonyms	1-Boc-3-(4-Fluoroanilino)piperidine; tert-Butyl 3-[(4-fluorophenyl)amino]piperidine-1-carboxylate; 1-(tert-Butoxycarbonyl)-3-[(4-fluorophenyl)amino]piperidine; 3-[(4-Fluorophenyl)amino]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; 1-Boc-3-(4-fluoro-phenylamino)-piperidine; Piperidine, 3-[(4-fluorophenyl)amino]-, 1-(1,1-dimethylethyl) ester; 816468-54-9; BOC-3-(4-Fluoro-Phenylamino)-Piperidine
EINECS	Contact for details

Quality Control

Our 1-Boc-3-(4-Fluoro-Phenylamino)-Piperidine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific project requirements, including development and GMP grades.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.