Description

3H-Oxazolo[3,4-A]Pyridine-5-Carboxylicacid,1-Ethyl-1,5,8,8A-Tetrahydro-3-Oxo-,(1S,5S,8As)-(9Ci) is a high-purity chiral intermediate with significant synthetic utility. This compound is valued for its rigid, fused bicyclic structure which serves as a key building block in advanced pharmaceutical research and development. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and fine chemical industries for the synthesis of novel active pharmaceutical ingredients (APIs) and other complex organic molecules.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of new therapeutic agents, particularly in central nervous system (CNS) and antiviral drug candidates.
• Asymmetric Synthesis: Utilized as a scaffold or precursor in stereoselective synthesis to introduce complex molecular architecture with defined stereochemistry.
• Medicinal Chemistry Research: Serves as a core structure for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Process Chemistry Development: Used in scaling up synthetic routes for potential APIs, where its defined stereochemistry is crucial for regulatory approval.
• Academic Research: Employed in universities and research institutes for methodological studies in heterocyclic and organocatalysis chemistry.
• Fine Chemical Production: Acts as a specialized intermediate for the custom synthesis of complex, high-value organic compounds.

Basic Information

Product Name	3H-Oxazolo[3,4-A]Pyridine-5-Carboxylicacid,1-Ethyl-1,5,8,8A-Tetrahydro-3-Oxo-,(1S,5S,8As)-(9Ci)
CAS No.	816453-12-0
Molecular Formula	C11H13NO4
Molecular Weight	223.23 g/mol
Synonyms	(1S,5S,8aS)-1-Ethyl-3-oxo-1,5,8,8a-tetrahydro-3H-oxazolo[3,4-a]pyridine-5-carboxylic acid; 1-Ethyl-1,5,8,8a-tetrahydro-3-oxo-3H-oxazolo[3,4-a]pyridine-5-carboxylic acid, (1S,5S,8aS)-; (1S,5S,8aS)-1-Ethyl-3-oxo-2,3,5,8,8a,9-hexahydro-1H-oxazolo[3,4-a]pyridine-5-carboxylic acid; 816453-12-0; (1S,5S,8aS)-1-Ethyl-1,5,8,8a-tetrahydro-3-oxo-3H-oxazolo[3,4-a]pyridine-5-carboxylic acid; Oxazolopyridine carboxylic acid derivative.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity. Quality is verified through comprehensive analytical techniques including HPLC, chiral HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles. We support development under cGMP guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The container should be kept in a well-ventilated area. For long-term storage, consider under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.