Description

3H-Oxazolo[3,4-A]Pyridine-5-Carboxylicacid,1-Ethyl-1,5,8,8A-Tetrahydro-3-Oxo-,(1S,5R,8As)-(9Ci) CAS NO 816452-92-3 is a high-purity, stereochemically defined heterocyclic building block of significant interest in advanced organic synthesis. This compound matters as a key chiral intermediate for the research and development of novel pharmaceutical agents, particularly in the creation of complex molecules with specific biological activities. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to incorporate its unique fused oxazolo-pyridine scaffold into new molecular entities.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral building block in the synthesis of potential active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and anti-infective drug candidates.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical space and biological targets.
• Process Chemistry Development: Employed in scaling up synthetic routes for novel compounds, benefiting from its defined stereochemistry for consistent results.
• Agrochemical Synthesis: Acts as a precursor in the development of new herbicides or insecticides with novel modes of action.
• Academic Research: Utilized in universities and research institutes for methodological studies in asymmetric synthesis and heterocyclic chemistry.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.

Basic Information

Product Name	3H-Oxazolo[3,4-A]Pyridine-5-Carboxylicacid,1-Ethyl-1,5,8,8A-Tetrahydro-3-Oxo-,(1S,5R,8As)-(9Ci)
CAS No.	816452-92-3
Molecular Formula	C11H13NO4
Molecular Weight	223.23 g/mol
Synonyms	(1S,5R,8aR)-1-Ethyl-3-oxo-1,5,6,7,8,8a-hexahydro-3H-oxazolo[3,4-a]pyridine-5-carboxylic acid; 1-Ethyl-1,5,8,8a-tetrahydro-3-oxo-3H-oxazolo[3,4-a]pyridine-5-carboxylic acid, (1S,5R,8aR)-; (1S,5R,8aR)-1-Ethyl-3-oxo-1,5,6,7,8,8a-hexahydro-3H-[1,3]oxazolo[3,4-a]pyridine-5-carboxylic acid; 816452-92-3; SCHEMBL21802227; AKOS040759626; A-1431; ZINC000257630007.
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced and analyzed under strict quality management protocols. We provide comprehensive Certificates of Analysis (COA) that detail purity, chiral purity, and impurity profiles, ensuring traceability and consistency for your critical R&D and scale-up work. Our quality systems are designed to support cGMP compliance for pharmaceutical applications, with documentation practices that facilitate regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.