Description

Methyl 4-(Hydroxymethyl)Thiophene-2-Carboxylate is a versatile heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its bifunctional structure, featuring both a carboxylate ester and a hydroxymethyl group on a thiophene core, enabling diverse chemical modifications. It is primarily needed by pharmaceutical and agrochemical R&D teams for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and anti-inflammatory pathways.
• Agrochemical Synthesis: Serves as a precursor for developing new herbicides and fungicides with thiophene-based active ingredients.
• Material Science: Used in the research and production of specialty polymers and organic electronic materials, such as conductive polymers and organic semiconductors.
• Ligand and Catalyst Development: Acts as a starting material for creating novel ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Chemical Research: Employed in academic and industrial laboratories for method development and exploring new heterocyclic chemistry.
• Fine Chemical Production: Integral to the multi-step synthesis of complex flavors, fragrances, and other high-value specialty chemicals.

Basic Information

Product Name	Methyl 4-(Hydroxymethyl)Thiophene-2-Carboxylate
CAS No.	816449-72-6
Molecular Formula	C7H8O3S
Molecular Weight	172.20 g/mol
Synonyms	2-Thiophenecarboxylic acid, 4-(hydroxymethyl)-, methyl ester; Methyl 4-(hydroxymethyl)thiophene-2-carboxylate; 4-(Hydroxymethyl)thiophene-2-carboxylic acid methyl ester; Methyl 4-hydroxymethylthiophene-2-carboxylate; 2-Methoxycarbonyl-4-hydroxymethylthiophene; 4-Hydroxymethyl-2-thiophenecarboxylic acid methyl ester; 4-(Hydroxymethyl)-2-thiophenecarboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our production of Methyl 4-(Hydroxymethyl)Thiophene-2-Carboxylate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.