Description

Pyridine, 2-Bromo-4-[[[(1,1-Dimethylethyl)dimethylsilyl]oxy]methyl]- is a specialized organosilicon-protected pyridine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the dual functionality of the bromo and silyl-protected hydroxymethyl groups, which allow for selective and sequential modifications under mild conditions. This high-purity intermediate is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active compounds, particularly where precise control over molecular architecture is required.

Application

• Pharmaceutical Intermediate: Key synthon for the construction of complex drug candidates, especially in medicinal chemistry programs targeting kinase inhibitors and other heterocyclic-based therapeutics.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, leveraging its pyridine core for bioactivity.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing sophisticated ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the creation of functionalized organic molecules for advanced materials, such as organic semiconductors or liquid crystals.
• Custom Synthesis and Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.

Basic Information

Product Name	Pyridine, 2-Bromo-4-[[[(1,1-Dimethylethyl)dimethylsilyl]oxy]methyl]-
CAS No.	815584-38-4
Molecular Formula	C13H22BrNOSi
Molecular Weight	316.31 g/mol
Synonyms	2-Bromo-4-((tert-butyldimethylsilyloxy)methyl)pyridine; 4-((tert-Butyldimethylsilyloxy)methyl)-2-bromopyridine; 2-Bromo-4-(((tert-butyldimethylsilyl)oxy)methyl)pyridine; 2-Bromo-4-((TBDMSoxy)methyl)pyridine; 2-Bromo-4-(hydroxymethyl)pyridine tert-butyldimethylsilyl ether; TBDMS ether of 2-Bromo-4-(hydroxymethyl)pyridine; 2-Br-4-CH2OTBDMS-Pyridine
EINECS	Contact for details

Quality Control

Every batch of Pyridine, 2-Bromo-4-[[[(1,1-Dimethylethyl)dimethylsilyl]oxy]methyl]- is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and process chemistry. A detailed Certificate of Analysis (COA) confirming identity, purity (typically ≥95% by HPLC), and impurity profile is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its moisture-sensitive (hygroscopic) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (GC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.