Description

1,3-Dioxaspiro[4.5]Decan-7-One,2,2,6,6-Tetramethyl-8-Methylene-,(5S)-(9Ci) is a high-purity, stereochemically defined spirocyclic compound that serves as a versatile and valuable chiral building block in advanced organic synthesis. Its unique rigid structure and defined stereochemistry make it an essential intermediate for constructing complex molecules with precise spatial orientation. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-infective therapeutic areas.
• Agrochemical Research: Used in the development of new pesticides and herbicides, where its spirocyclic structure can contribute to unique biological activity.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for synthesizing sophisticated chiral ligands and organocatalysts.
• Material Science: Building block for creating novel polymers and advanced organic materials with specific optical or mechanical properties.
• Academic & Process Chemistry: Employed in methodological development and scale-up studies for complex organic transformations.

Basic Information

Product Name	1,3-Dioxaspiro[4.5]Decan-7-One,2,2,6,6-Tetramethyl-8-Methylene-,(5S)-(9Ci)
CAS No.	810682-41-8
Molecular Formula	C13H20O3
Molecular Weight	224.30 g/mol
Synonyms	(5S)-2,2,6,6-Tetramethyl-8-methylene-1,3-dioxaspiro[4.5]decan-7-one; (5S)-8-Methylene-2,2,6,6-tetramethyl-1,3-dioxaspiro[4.5]decan-7-one; Spiro[1,3-dioxolane-2,9'-bicyclo[3.3.1]nonan]-7'-one, 4,4,8,8-tetramethyl-2-methylene-, (5'S)-; Tetramethyl Methylene Spiroketal; Chiral Spiroketal Building Block.
EINECS	Contact for details

Quality Control

Every batch of 1,3-Dioxaspiro[4.5]Decan-7-One,2,2,6,6-Tetramethyl-8-Methylene-,(5S)-(9Ci) is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and chiral integrity, meeting the stringent requirements of research and pre-clinical development. A detailed Certificate of Analysis (COA) including chiral purity (enantiomeric excess) is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.