Description

Mal-Peg1-T-Butyl Ester is a specialized bifunctional PEG derivative featuring a maleimide group and a protected carboxylic acid. This compound is a crucial building block in bioconjugation chemistry, enabling the precise and stable attachment of biomolecules. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for developing advanced therapeutics, including antibody-drug conjugates (ADCs) and peptide-based drugs.

Application

• Bioconjugation Linker: Serves as a key reagent for covalently linking peptides, proteins, or antibodies to drugs, dyes, or other functional molecules via thiol-maleimide chemistry.
• Antibody-Drug Conjugate (ADC) Development: Used in the synthesis of linker-payload constructs for targeted cancer therapies.
• PEGylation Reagent: Facilitates the site-specific PEGylation of therapeutic proteins to enhance solubility, stability, and circulation half-life.
• Diagnostic Probe Synthesis: Employed in creating fluorescent or radioactive probes for imaging and diagnostic applications.
• Surface Functionalization: Used to modify nanoparticles, biosensors, or chromatographic media with reactive maleimide groups for biomolecule immobilization.
• Cross-linking Agent: Acts as a heterobifunctional cross-linker in material science and hydrogel formation for controlled drug delivery systems.

Basic Information

Product Name	Mal-Peg1-T-Butyl Ester
CAS No.	810677-16-8
Molecular Formula	C13H21NO5
Molecular Weight	271.31 g/mol
Synonyms	1-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3,6,9,12-tetraoxapentadecan-15-oic acid tert-butyl ester; Maleimide-PEG1-t-butyl ester; tert-Butyl 17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3,6,9,12,15-pentaoxaheptadecanoate; 3,6,9,12-Tetraoxapentadecanoic acid, 1-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-, 1,1-dimethylethyl ester; Mal-PEG1-OtBu; Maleimide-PEG1-acid t-butyl ester
EINECS	Contact for details

Quality Control

Our Mal-Peg1-T-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.