Description

3-Isocyanato-1-(Trifluoroacetyl)Piperidine is a specialized heterocyclic building block that combines a reactive isocyanate group with a trifluoroacetyl moiety. This unique structure makes it a valuable intermediate for synthesizing novel compounds with enhanced biological activity and physicochemical properties. It is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for creating new active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel piperidine-based drug candidates, particularly in central nervous system (CNS) and metabolic disorder research.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the trifluoromethyl group can improve lipophilicity and metabolic stability.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers, coatings, and resins with unique chemical resistance.
• Chemical Biology Probes: Utilized to create isocyanate-reactive probes for studying enzyme activity or protein labeling due to its specific reactivity profile.
• Custom Synthesis & Contract Manufacturing: A critical reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	3-Isocyanato-1-(Trifluoroacetyl)Piperidine
CAS No.	808764-41-2
Molecular Formula	C8H9F3N2O2
Molecular Weight	222.17 g/mol
Synonyms	1-(Trifluoroacetyl)-3-isocyanatopiperidine; 3-Isocyanato-1-(2,2,2-trifluoroacetyl)piperidine; Piperidine, 3-isocyanato-1-(trifluoroacetyl)-; 808764-41-2; 1-(3-Isocyanatopiperidin-1-yl)-2,2,2-trifluoroethan-1-one
EINECS	Contact for details

Quality Control

Our 3-Isocyanato-1-(Trifluoroacetyl)Piperidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability, consistency, and reliability for your critical synthesis work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation by moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.