Description

L-Proline, 4-(Difluoromethylene)-, Methyl Ester (9Ci) is a specialized, non-proteinogenic proline derivative featuring a difluoromethylene group at the 4-position. This compound is a critical fluorinated building block in modern organic synthesis, prized for its ability to modulate the physicochemical and metabolic properties of target molecules. It is primarily utilized by pharmaceutical research and agrochemical development teams for the creation of novel bioactive compounds, including protease inhibitors and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key fluorinated synthon for the research and development of novel drug candidates, particularly in protease inhibitor programs.
• Agrochemical Synthesis: Used in the design and synthesis of advanced pesticides and herbicides, where the difluoromethylene group enhances biological activity and stability.
• Peptidomimetics & Bioactive Peptides: Serves as a constrained, fluorinated amino acid analog for constructing peptide-based therapeutics and diagnostic tools.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to investigate the effects of fluorination on potency, selectivity, and metabolic profile.
• Chemical Biology Probes: Useful for labeling and probing enzyme active sites or for incorporation into activity-based probes.
• Advanced Material Science: Potential monomer or precursor for specialty polymers with unique surface properties.

Basic Information

Product Name	L-Proline, 4-(Difluoromethylene)-, Methyl Ester (9Ci)
CAS No.	808154-66-7
Molecular Formula	C7H9F2NO2
Molecular Weight	177.15 g/mol
Synonyms	4-(Difluoromethylene)-L-proline methyl ester; Methyl (2S)-4-(difluoromethylene)pyrrolidine-2-carboxylate; (2S)-4-(Difluoromethylene)pyrrolidine-2-carboxylic acid methyl ester; L-4,4-Difluoromethylene-proline methyl ester; Fluorinated L-Proline methyl ester; Difluoromethylene proline derivative; 808154-66-7; 9CI-labeled L-Proline derivative
EINECS	Contact for details

Quality Control

Our L-Proline, 4-(Difluoromethylene)-, Methyl Ester is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric excess, and spectroscopic identification (NMR, IR, MS). We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.