Description

2-Oxabicyclo[3.2.1]Octane-6-Aceticacid,3-Oxo-,Methylester,(1R,5R,6R)-(9Ci) is a high-purity, stereochemically defined bicyclic lactone derivative that serves as a critical chiral building block and advanced pharmaceutical intermediate. Its unique bridged oxabicyclic structure provides a rigid, three-dimensional framework essential for imparting specific biological activity and stereochemical control in complex synthetic pathways. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and anti-infective therapies.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates and proprietary APIs.
• Asymmetric Synthesis: Employed as a scaffold for constructing stereocenters in natural product synthesis and medicinal chemistry programs.
• Chemical Research: Used in academic and industrial R&D for studying reaction mechanisms and developing new catalytic methodologies.
• Ligand & Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts.
• Fine Chemical Production: Integral to the manufacture of high-value specialty chemicals with specific stereochemical requirements.

Basic Information

Product Name	2-Oxabicyclo[3.2.1]Octane-6-Aceticacid,3-Oxo-,Methylester,(1R,5R,6R)-(9Ci)
CAS No.	802911-61-1
Molecular Formula	C10H14O4
Molecular Weight	198.22 g/mol
Synonyms	(1R,5R,6R)-Methyl 3-oxo-2-oxabicyclo[3.2.1]octane-6-acetate; (1R,5R,6R)-6-(Methoxycarbonylmethyl)-3-oxo-2-oxabicyclo[3.2.1]octane; Methyl (1R,5R,6R)-3-oxo-2-oxabicyclo[3.2.1]octane-6-acetate; (1R,5R,6R)-3-Oxo-2-oxabicyclo[3.2.1]octane-6-acetic acid methyl ester; Bicyclic γ-lactone ester; Chiral oxabicyclo[3.2.1]octanone derivative.
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced under strict quality management systems and undergoes comprehensive analytical characterization to ensure identity, purity, and stereochemical integrity. Standard quality assurance includes HPLC for chiral purity, NMR for structural confirmation, and specific tests for residual solvents and moisture. A detailed Certificate of Analysis (COA) is provided with each shipment, and custom synthesis to meet specific pharmacopeial or internal specifications is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and potential degradation. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.