Description

2-Pyridinecarbonitrile,4-[(2-Methyl-1H-Imidazol-4-Yl)Ethynyl]-(9Ci) is a specialized heterocyclic building block featuring a pyridine core linked to a methylimidazole moiety via an ethynyl bridge. This compound matters as a high-value pharmaceutical intermediate and key synthon for medicinal chemistry research, enabling the synthesis of complex molecules with targeted biological activity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors working on kinase inhibitors and other small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel drug candidates, particularly kinase inhibitors.
• Medicinal Chemistry Research: Used as a versatile building block for constructing compound libraries via cross-coupling reactions.
• Agrochemical Development: Employed in the research and development of new active ingredients for crop protection.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and cellular pathways.
• Material Science: Acts as a ligand or functional component in the development of advanced coordination polymers and metal-organic frameworks (MOFs).
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds under cGMP or research-grade conditions.

Basic Information

Product Name	2-Pyridinecarbonitrile,4-[(2-Methyl-1H-Imidazol-4-Yl)Ethynyl]-(9Ci)
CAS No.	802906-44-1
Molecular Formula	C12H8N4
Molecular Weight	208.22 g/mol
Synonyms	4-[(2-Methyl-1H-imidazol-4-yl)ethynyl]pyridine-2-carbonitrile; 4-[(2-Methyl-1H-imidazol-4-yl)ethynyl]-2-pyridinecarbonitrile; 4-(2-Methylimidazol-4-ylethynyl)picolinonitrile; 2-Cyano-4-[(2-methyl-1H-imidazol-4-yl)ethynyl]pyridine; 4-(2-Methyl-1H-imidazol-4-ylethynyl)-2-pyridyl cyanide; Picolinonitrile, 4-[(2-methyl-1H-imidazol-4-yl)ethynyl]-; CAS 802906-44-1
EINECS	Contact for details

Quality Control

Our 2-Pyridinecarbonitrile,4-[(2-Methyl-1H-Imidazol-4-Yl)Ethynyl]-(9Ci) is produced under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with exacting research and development standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). This compound may be light-sensitive; prolonged exposure to light should be avoided. Keep container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.