Description

2-Pyridinecarbonitrile,4-[(Trimethylsilyl)Ethynyl]-(9Ci) is a specialized organosilicon building block featuring a pyridine core functionalized with both a nitrile and a trimethylsilyl-protected ethynyl group. This compound matters for its versatility as a key synthetic intermediate in advanced organic and medicinal chemistry, enabling the construction of complex molecular architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for applications such as drug discovery, ligand synthesis, and the development of functional polymers.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing functionalized pyridine or acetylene motifs.
• Agrochemical Synthesis: Used in the research and development of novel crop protection agents and herbicides, where its structural features can impart specific biological activity.
• Material Science & Organic Electronics: Acts as a precursor for conjugated polymers and small molecules used in organic light-emitting diodes (OLEDs), organic photovoltaics (OPVs), and other electronic devices.
• Ligand & Catalyst Development: Employed in the preparation of novel nitrogen-containing ligands for transition metal catalysis, useful in cross-coupling and other synthetic transformations.
• Chemical Biology Probes: Utilized to create tagged or functionalized molecules for studying biological processes and protein interactions.
• Academic & Industrial Research: A valuable reagent for methodology development and exploring new chemical spaces in synthetic organic chemistry laboratories.

Basic Information

Product Name	2-Pyridinecarbonitrile,4-[(Trimethylsilyl)Ethynyl]-(9Ci)
CAS No.	802905-85-7
Molecular Formula	C11H12N2Si
Molecular Weight	200.32 g/mol
Synonyms	4-[(Trimethylsilyl)ethynyl]picolinonitrile; 4-((Trimethylsilyl)ethynyl)picolinonitrile; 4-(Trimethylsilylethynyl)picolinonitrile; 4-(2-Trimethylsilylethynyl)-2-pyridinecarbonitrile; 2-Cyano-4-((trimethylsilyl)ethynyl)pyridine; 4-(Trimethylsilylethynyl)-2-cyanopyridine; 4-Ethynyl-2-cyanopyridine, TMS-protected; Picolinonitrile, 4-[(trimethylsilyl)ethynyl]-
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch of 2-Pyridinecarbonitrile,4-[(Trimethylsilyl)Ethynyl]-(9Ci) is analyzed using advanced techniques including HPLC, GC, NMR, and mass spectrometry to confirm identity, purity, and the absence of critical impurities. Certificates of Analysis (COA) detailing all relevant specifications are available upon request. We are committed to supplying material that meets the stringent requirements of research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.