Description

Spiro[Isoquinoline-1(2H),4-Piperidine], 3,4-Dihydro-1-Methyl- (8Ci) CAS NO 802280-08-6 is a high-purity, complex heterocyclic organic compound featuring a unique spirocyclic framework that integrates isoquinoline and piperidine pharmacophores. This structural motif makes it a critical intermediate for advanced pharmaceutical research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in developing new therapeutic agents targeting the central nervous system and other disease areas.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those with potential neurological activity.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its privileged spirocyclic scaffold.
• Chemical Reference Standard: Serves as a high-purity analytical standard for method development and quality control in API manufacturing.
• Academic Research: Employed in universities and research institutes for studying heterocyclic chemistry, reaction mechanisms, and new synthetic methodologies.
• Precursor for Specialty Chemicals: Used in the development of advanced materials, ligands for catalysis, or other functionalized fine chemicals.

Basic Information

Product Name	Spiro[Isoquinoline-1(2H),4-Piperidine], 3,4-Dihydro-1-Methyl- (8Ci)
CAS No.	802280-08-6
Molecular Formula	C14H18N2
Molecular Weight	214.31 g/mol
Synonyms	1-Methyl-1,2,3,4-tetrahydrospiro[isoquinoline-1,4'-piperidine]; 3,4-Dihydro-1-methylspiro[isoquinoline-1(2H),4'-piperidine]; Spiro[isoquinoline-1(2H),4'-piperidine], 3,4-dihydro-1-methyl-; 1-Methyl-3,4-dihydro-1H-spiro[isoquinoline-1,4'-piperidine]; 1'-Methyl-1,2,3,4-tetrahydrospiro[isoquinoline-1,4'-piperidine]; Tetrahydrospiro[isoquinoline-1,4'-piperidine] derivative; 802280-08-6
EINECS	Contact for details

Quality Control

Our Spiro[Isoquinoline-1(2H),4-Piperidine], 3,4-Dihydro-1-Methyl- (8Ci) is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing including HPLC, NMR, and mass spectrometry to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and development purposes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound may be hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.