Description

Ethyl 1-[3-(Trifluoromethyl)Pyridin-2-Yl]Piperidine-4-Carboxylate is a high-value, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where the trifluoromethylpyridine moiety is prized for its ability to modulate lipophilicity, metabolic stability, and bioavailability. Pharmaceutical and agrochemical R&D teams need this precise chemical scaffold to accelerate the discovery and optimization of new candidate molecules targeting a range of therapeutic and crop protection applications.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates, particularly in central nervous system (CNS), oncology, and anti-infective research pipelines.
• Agrochemical Synthesis: Serves as a key precursor for developing advanced herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Used in the construction of linkers and warheads for targeted protein degradation platforms.
• Material Science Research: Employed in the development of specialty chemicals, liquid crystals, and advanced polymers requiring fluorinated aromatic systems.
• Contract Research & Development (CRO/CMO): Supplied to research organizations for custom synthesis and process development projects.
• Academic Research: Utilized in university and institutional labs for methodological studies in fluorination chemistry and heterocycle synthesis.

Basic Information

Product Name	Ethyl 1-[3-(Trifluoromethyl)Pyridin-2-Yl]Piperidine-4-Carboxylate
CAS No.	801306-50-3
Molecular Formula	C14H17F3N2O2
Molecular Weight	302.29 g/mol
Synonyms	Ethyl 1-(3-(trifluoromethyl)pyridin-2-yl)piperidine-4-carboxylate; 1-[3-(Trifluoromethyl)-2-pyridinyl]-4-piperidinecarboxylic Acid Ethyl Ester; 4-Piperidinecarboxylic acid, 1-[3-(trifluoromethyl)-2-pyridinyl]-, ethyl ester; Ethyl 1-(3-trifluoromethylpyridin-2-yl)piperidine-4-carboxylate; CAS 801306-50-3; 2-(4-Ethoxycarbonylpiperidin-1-yl)-3-(trifluoromethyl)pyridine
EINECS	Contact for details

Quality Control

Our Ethyl 1-[3-(Trifluoromethyl)Pyridin-2-Yl]Piperidine-4-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) detailing all specifications are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.