Description

1-Thia-4,8-Diazaspiro[4.5]Decan-3-One,8-Methyl-,1,1-Dioxide(8Ci) is a high-purity, advanced pharmaceutical intermediate belonging to the spirocyclic sulfonamide class of heterocyclic compounds. This compound is valued for its unique structural framework, which serves as a critical building block in modern medicinal chemistry for the development of novel therapeutic agents. It is primarily sought by research institutions and pharmaceutical companies engaged in the synthesis of new chemical entities, particularly for central nervous system (CNS) and metabolic disorder targets.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of novel drug candidates, especially those targeting neurological pathways.
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing complex molecular libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Protease Inhibitor Development: The spirocyclic sulfonamide core is relevant in the design of inhibitors for various enzymes, including proteases involved in disease processes.
• Chemical Biology Probes: Serves as a starting material for creating specialized molecular probes to study biological mechanisms and protein function.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the cGMP production of active pharmaceutical ingredients (APIs) at various scales.

Basic Information

Product Name	1-Thia-4,8-Diazaspiro[4.5]Decan-3-One,8-Methyl-,1,1-Dioxide(8Ci)
CAS No.	801213-04-7
Molecular Formula	C8H14N2O3S
Molecular Weight	218.27 g/mol
Synonyms	8-Methyl-1-thia-4,8-diazaspiro[4.5]decan-3-one 1,1-dioxide; 8-Methyl-1-thia-4,8-diazaspiro[4.5]decan-3-one 1,1-dioxide (8CI); 1-Thia-4,8-diazaspiro[4.5]decan-3-one, 8-methyl-, 1,1-dioxide; 8-Methyl-1,1-dioxo-1-thia-4,8-diazaspiro[4.5]decan-3-one; Spirocyclic sulfonamide intermediate; 801213-04-7
EINECS	Contact for details

Quality Control

Our 1-Thia-4,8-Diazaspiro[4.5]Decan-3-One,8-Methyl-,1,1-Dioxide(8Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS), to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with complete batch traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.