Description

trans-2-(Pyridin-4-Yl)Cyclopropanecarboxylic Acid is a high-purity, functionalized cyclopropane derivative that serves as a critical chiral building block in advanced organic synthesis. Its unique rigid structure, incorporating both a pyridine ring and a carboxylic acid group, makes it a versatile intermediate for constructing complex molecules with precise stereochemistry. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients and exploring new chemical spaces.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of active pharmaceutical ingredients (APIs), especially in medicinal chemistry programs targeting CNS disorders and infectious diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, where its cyclopropane scaffold can contribute to improved biological activity and stability.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of functional organic molecules and polymers for electronic or photonic applications.
• Chemical Biology Probes: Utilized as a core structure in designing molecular probes and inhibitors for studying enzyme function and biological pathways.

Basic Information

Product Name	trans-2-(Pyridin-4-Yl)Cyclopropanecarboxylic Acid
CAS No.	801149-24-6
Molecular Formula	C9H9NO2
Molecular Weight	163.17 g/mol
Synonyms	trans-2-(4-Pyridyl)cyclopropanecarboxylic Acid; (1R,2S)-rel-2-(4-Pyridinyl)cyclopropanecarboxylic Acid; 2-(Pyridin-4-yl)cyclopropane-1-carboxylic Acid; 4-(2-Carboxycyclopropyl)pyridine; (1R,2S)-2-(4-Pyridyl)cyclopropanecarboxylic Acid; (1S,2R)-2-(4-Pyridyl)cyclopropanecarboxylic Acid; 801149-24-6; trans-2-(4-Pyridinyl)cyclopropanecarboxylic Acid
EINECS	Contact for details

Quality Control

Our trans-2-(Pyridin-4-Yl)Cyclopropanecarboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure it meets the high standards required for research and process development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using a desiccant.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.