Description

Ethyl 2-Bromoisonicotinate is a versatile brominated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its reactive bromine atom and ester functionality, enabling precise molecular construction for complex target compounds. This high-purity intermediate is essential for research and development chemists in the pharmaceutical, agrochemical, and material science industries seeking to develop new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other nitrogen-containing heterocycles.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the pyridine core is a common bioactive motif.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and coordination chemistry.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as charge-transport layers or light-emitting components.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Functional Group Transformation: The ethyl ester group can be hydrolyzed to the corresponding acid or reduced to the alcohol, providing access to a suite of related derivatives.

Basic Information

Product Name	Ethyl 2-Bromoisonicotinate
CAS No.	89978-52-9
Molecular Formula	C8H8BrNO2
Molecular Weight	230.06 g/mol
Synonyms	2-Bromoisonicotinic Acid Ethyl Ester; Ethyl 2-Bromo-4-pyridinecarboxylate; 4-Pyridinecarboxylic acid, 2-bromo-, ethyl ester; 2-Bromo-4-(ethoxycarbonyl)pyridine; Isonicotinic acid, 2-bromo-, ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 2-Bromoisonicotinate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. A Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee batch-to-batch consistency and support your regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.