Description

3-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Propanenitrile is a specialized organosilicon-protected cyanoalkyl reagent, a key building block in advanced organic synthesis. Its primary value lies in its role as a protected cyanohydrin equivalent, offering chemists a stable and versatile handle for introducing nitrile and subsequent functional groups under mild conditions. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and fine chemical industries engaged in the synthesis of complex molecules, heterocycles, and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A crucial synthon for constructing β-amino alcohols, γ-amino acids, and other nitrogen-containing pharmacophores via nitrile group transformation.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and plant growth regulators that require specific nitrile or amine functionalities.
• Fine Chemical Manufacturing: Serves as a protected precursor in multi-step syntheses of dyes, flavors, fragrances, and advanced materials.
• Peptide Mimetics & Heterocycle Construction: The tert-butyldimethylsilyl (TBDMS) protected cyanohydrin moiety is valuable for creating non-peptidic scaffolds and various nitrogen heterocycles like pyrroles and pyridines.
• Polymer Chemistry: Can be utilized as a monomer or chain-transfer agent in the synthesis of specialty polymers with tailored properties.
• Cross-Coupling Reactions: Acts as an electrophilic partner in palladium-catalyzed or other metal-mediated coupling reactions to form new carbon-carbon bonds.

Basic Information

Product Name	3-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Propanenitrile
CAS No.	89923-33-1
Molecular Formula	C9H19NOSi
Molecular Weight	185.34 g/mol
Synonyms	3-[(tert-Butyldimethylsilyl)oxy]propanenitrile; 3-(TBDMS-oxy)propionitrile; 3-((tert-Butyldimethylsilyl)oxy)propanenitrile; 2-Cyanoethyl tert-butyldimethylsilyl ether; TBDMS-protected 3-hydroxypropionitrile; tert-Butyldimethyl(2-cyanoethoxy)silane; 3-(tert-Butyldimethylsiloxy)propionitrile; β-Cyanoethyl tert-butyldimethylsilyl ether
EINECS	Contact for details

Quality Control

Our 3-[[(1,1-Dimethylethyl)Dimethylsilyl]Oxy]Propanenitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.