Description

4-Pyridinecarboxamide, N,3-Dihydroxy- is a versatile heterocyclic building block and intermediate of significant interest in advanced organic synthesis. This compound, with CAS number 89640-77-7, is valued for its bifunctional structure, featuring both a hydroxypyridine and a hydroxamic acid moiety, which enables its use in creating complex molecular architectures. It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly those targeting metalloenzymes (e.g., histone deacetylase inhibitors) or requiring metal-chelating properties.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and plant growth regulators that leverage its chelating ability and heterocyclic core.
• Ligand Synthesis: Serves as a precursor for the preparation of sophisticated polydentate ligands used in catalysis, material science, and medicinal inorganic chemistry.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and metal ion homeostasis in biological systems.
• Coordination Chemistry: Acts as a starting material for creating metal-organic frameworks (MOFs) and complexes with applications in sensing and catalysis.
• Academic & Industrial R&D: A valuable reagent for methodological studies and exploratory synthesis in organic and medicinal chemistry laboratories worldwide.

Basic Information

Product Name	4-Pyridinecarboxamide, N,3-Dihydroxy-
CAS No.	89640-77-7
Molecular Formula	C6H6N2O3
Molecular Weight	154.12 g/mol
Synonyms	3-Hydroxyisonicotinohydroxamic Acid; N,3-Dihydroxyisonicotinamide; 3-Hydroxy-4-pyridinecarbohydroxamic Acid; 3-Hydroxyisonicotinic Acid Hydroxamide; 4-Carbamoyl-3-hydroxypyridine N-Oxide (tautomer); Isonicotinohydroxamic Acid, 3-Hydroxy-; 3-Hydroxy-pyridine-4-carboxylic acid hydroxamide
EINECS	Contact for details

Quality Control

Our 4-Pyridinecarboxamide, N,3-Dihydroxy- is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals, to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation by atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.