Description

2-Trimethylsilylethyl 2-Bromo-2-methylpropanoate is a specialized organosilicon-protected α-bromo ester, a key building block in advanced organic synthesis. This compound matters for its role as a versatile precursor in the controlled introduction of the 2-bromo-2-methylpropionyl moiety under mild conditions, enabling the synthesis of complex molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for constructing novel polymers, bioactive compounds, and functional materials.

Application

• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing tert-butyl-like groups or as a protected form of methacrylic acid derivatives.
• Polymer Chemistry & Material Science: Serves as a functional monomer or initiator in controlled radical polymerization (e.g., ATRP - Atom Transfer Radical Polymerization) to create well-defined polymers and block copolymers.
• Agrochemical Synthesis: Employed as a key synthon for constructing complex molecules with potential herbicidal or insecticidal activity.
• Peptide Modification & Bioconjugation: Acts as an acylating agent for modifying peptides, proteins, or other biomolecules, leveraging the silyl-protecting group for selective deprotection.
• Ligand & Catalyst Development: Utilized in the preparation of novel ligands and organometallic catalysts for asymmetric synthesis.
• Surface Functionalization: Applied to modify the surface properties of silica, glass, or other materials by grafting the reactive ester group.

Basic Information

Product Name	2-Trimethylsilylethyl 2-Bromo-2-methylpropanoate
CAS No.	89604-95-5
Molecular Formula	C9H19BrO2Si
Molecular Weight	267.24 g/mol
Synonyms	2-(Trimethylsilyl)ethyl 2-bromo-2-methylpropanoate; 2-Bromo-2-methylpropanoic Acid 2-(Trimethylsilyl)ethyl Ester; 2-(Trimethylsilyl)ethyl α-bromoisobutyrate; TMS-Ethyl 2-Bromo-2-methylpropionate; 2-Bromo-2-methylpropionic Acid Trimethylsilylethyl Ester; (2-Bromo-2-methylpropanoyloxy)ethyltrimethylsilane; 2-Trimethylsilylethyl α-Bromoisobutyrate
EINECS	Contact for details

Quality Control

Our 2-Trimethylsilylethyl 2-Bromo-2-methylpropanoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and GC, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.