Description

(+/-)-Boc-α-Phosphonoglycine Trimethyl Ester CAS NO 89524-98-1 is a high-purity, protected phosphonoglycine derivative, a crucial building block in modern organic synthesis. Its primary value lies in enabling the controlled introduction of the phosphonoglycine moiety, a key structural motif for creating novel amino acid analogs and enzyme inhibitors. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for developing protease inhibitors, transition-state analogs, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel amino acid-based drugs, including protease and peptidase inhibitors.
• Peptidomimetic Research: Used to create phosphonate-containing peptide analogs that mimic transition states for drug discovery programs.
• Agrochemical Development: Serves as a building block for designing new herbicides and plant growth regulators with unique modes of action.
• Chemical Biology Probes: Enables the synthesis of activity-based probes and inhibitors for studying enzyme mechanisms.
• Organocatalyst & Ligand Synthesis: Used in the preparation of chiral phosphonate-containing ligands for asymmetric catalysis.
• Material Science: A precursor for functionalized monomers that can be incorporated into specialty polymers.

Basic Information

Item	Detail
Product Name	(+/-)-Boc-α-Phosphonoglycine Trimethyl Ester
CAS No.	89524-98-1
Molecular Formula	C₁₀H₂₀NO₇P
Molecular Weight	297.24 g/mol
Synonyms	tert-Butyl (dimethoxyphosphoryl)(methoxycarbonyl)methylcarbamate; (Boc-NH-CH(PO(OMe)₂)-COOMe); N-(tert-Butoxycarbonyl)-α-phosphonoglycine trimethyl ester; Boc-α-phosphonoglycine-OMe; α-((tert-Butoxycarbonyl)amino)-α-(dimethoxyphosphinyl)acetic acid methyl ester; Phosphonoglycine Boc-OMe; (Carbomethoxy)(dimethoxyphosphinyl)methyl]carbamic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Every batch of (+/-)-Boc-α-Phosphonoglycine Trimethyl Ester is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and development. A Certificate of Analysis (COA) detailing purity (typically by HPLC/NMR), identity, and impurity profiles is supplied with each shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is compatible with strong acid/organic solvent environments but should be kept under inert atmosphere for long-term storage to maintain optimal stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.