Description

Methyl 1-Hydroxycyclobutanecarboxylate is a versatile and high-value organic building block featuring both a hydroxyl and an ester functional group on a strained cyclobutane ring. This unique structure makes it a critical intermediate in modern synthetic organic chemistry, particularly for the construction of complex pharmaceutical molecules and advanced materials. It is primarily sought after by research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries for applications in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel active pharmaceutical ingredients (APIs), especially those containing constrained ring systems.
• Medicinal Chemistry Building Block: Used in drug discovery for scaffold hopping and the creation of proprietary compound libraries with improved metabolic stability and potency.
• Agrochemical Synthesis: Serves as a precursor in the development of new herbicides, fungicides, and insecticides with novel modes of action.
• Material Science Research: Employed in the synthesis of monomers for specialized polymers or as a ligand precursor in catalysis.
• Chemical Biology Probes: Useful for creating molecular probes to study enzyme function and biological pathways.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic synthesis, including ring-opening and functionalization reactions.

Basic Information

Product Name	Methyl 1-Hydroxycyclobutanecarboxylate
CAS No.	89489-58-7
Molecular Formula	C6H10O3
Molecular Weight	130.14 g/mol
Synonyms	1-Hydroxycyclobutanecarboxylic acid methyl ester; Methyl 1-hydroxycyclobutanecarboxylate; 1-Hydroxycyclobutane-1-carboxylic acid methyl ester; Methyl 1-hydroxy-1-cyclobutanecarboxylate; Cyclobutanecarboxylic acid, 1-hydroxy-, methyl ester; Methyl (1-hydroxycyclobutyl)formate
EINECS	Contact for details

Quality Control

Every batch of Methyl 1-Hydroxycyclobutanecarboxylate is produced and tested under strict quality management protocols to ensure consistency and reliability for your critical R&D and scale-up processes. Our standard grade meets high-purity specifications suitable for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its properties, the material should be handled in accordance with good laboratory practices to minimize exposure to moisture and strong bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.