Description

Peg-Azide, o-(2-Azidoethyl)-Oμ-Methylpolyethylene Glycol is a heterobifunctional polyethylene glycol (PEG) derivative featuring a reactive azide group at one terminus and a methoxy group at the other. This compound is a critical reagent in bioconjugation and click chemistry, enabling the efficient, site-specific coupling of biomolecules, polymers, and surfaces under mild, aqueous conditions. It is essential for researchers and manufacturers in pharmaceutical development, biotech, and advanced materials science, where it is used to create PEGylated therapeutics, diagnostic probes, and functional hydrogels.

Application

• Bioconjugation and Click Chemistry: Used as a linker for copper-catalyzed azide-alkyne cycloaddition (CuAAC) to attach drugs, peptides, or fluorescent labels to proteins, antibodies, or nanoparticles.
• PEGylation of Therapeutics: Conjugation to peptides, proteins, or oligonucleotides to enhance solubility, prolong circulation half-life, and reduce immunogenicity.
• Surface Functionalization: Modification of material surfaces (e.g., gold, silica, polymers) to create bio-inert or bioactive coatings for biosensors and medical devices.
• Polymer Synthesis: Serves as a macroinitiator or building block for synthesizing block copolymers, dendrimers, and cross-linked hydrogel networks.
• Diagnostic Reagent Production: Creation of labeled antibodies and imaging agents for assays like ELISA, flow cytometry, and in vivo imaging.
• Drug Delivery Systems: Fabrication of micelles, liposomes, and other nanocarriers for targeted and controlled drug release.

Basic Information

Item	Detail
Product Name	Peg-Azide, o-(2-Azidoethyl)-Oμ-Methylpolyethylene Glycol
CAS No.	89485-61-0
Molecular Formula	C2n+5H4n+11N3On+1 (n = PEG repeat units)
Molecular Weight	Variable (dependent on PEG chain length, e.g., 550, 750, 2000, 5000 Da)
Synonyms	mPEG-Azide; Methoxy PEG Azide; Azido-PEG-OMe; α-Methoxy-ω-azido PEG; Poly(ethylene glycol) methyl ether azide; O-(2-Azidoethyl)-O'-methylpolyethylene glycol; PEG Methyl Ether Azide; mPEG-N3
EINECS	Contact for details

Quality Control

Our Peg-Azide is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity, consistent molecular weight, and functional group integrity. A comprehensive Certificate of Analysis (COA) is provided, detailing specifications for identity, purity, azide content, and endotoxin levels where applicable, supporting use in GMP-compliant and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C or as indicated on the product label or COA. For long-term storage under inert atmosphere (argon or nitrogen), desiccate at -20°C. Handle as a moisture-sensitive material.

Specification

Item	Specification
Appearance	White to off-white waxy solid or viscous liquid
Identification (IR)	Conforms to structure
Average Molecular Weight (SEC/GPC)	As per ordered grade (e.g., 550, 2000, 5000 Da) ± 5%
Purity (HPLC)	≥ 95%
Azide Content (NMR/Titration)	≥ 90% of theoretical
Polydispersity Index (PDI)	≤ 1.05
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.