Description

(2R,4R)-2-Methylpiperidin-4-Ol CAS NO 89451-59-2 is a high-purity, chiral piperidine derivative that serves as a critical chiral building block and intermediate in advanced organic synthesis. Its defined stereochemistry is essential for imparting specific biological activity and physical properties to target molecules, making it invaluable for research and development. This compound is primarily sought after by pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of active pharmaceutical ingredients (APIs), ligands, and complex natural products.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the asymmetric synthesis of potential drug candidates, particularly for central nervous system (CNS) and cardiovascular targets.
• Agrochemical Synthesis: Used in the development of novel, stereospecific pesticides and herbicides where the specific enantiomer is crucial for efficacy and environmental safety.
• Catalyst & Ligand Preparation: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric hydrogenation and other enantioselective transformations.
• Academic & Industrial R&D: Employed in medicinal chemistry research for structure-activity relationship (SAR) studies and the exploration of new chemical entities.
• Fine Chemical Production: Integral to the multi-step synthesis of complex, high-value specialty chemicals and flavors & fragrances.

Basic Information

Product Name	(2R,4R)-2-Methylpiperidin-4-Ol
CAS No.	89451-59-2
Molecular Formula	C6H13NO
Molecular Weight	115.17 g/mol
Synonyms	(2R,4R)-2-Methyl-4-piperidinol; (2R,4R)-2-Methyl-4-hydroxypiperidine; (2R,4R)-4-Hydroxy-2-methylpiperidine; cis-2-Methyl-4-piperidinol; (2R,4R)-2-Methylpiperidin-4-ol; 4-Piperidinol, 2-methyl-, (2R,4R)-; 89451-59-2
EINECS	Contact for details

Quality Control

Our (2R,4R)-2-Methylpiperidin-4-Ol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for advanced synthetic applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed and away from direct light to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Enantiomeric Excess)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.